EXPERIMENTAL STUDY ON THE EFFECTS OF CYCLOPHOSPHAMIDE ON THE HEALING OF THE ORAL INCISED WOUND

Kim,  Seoung-Soo

J Korean Dent Assoc > Volume 15(2); 1977 > Article

The Journal of The Korean Dental Association 1977;15(2):153-158.
Published online February 28, 1977.

항암제 Cyclophosphamide가 구강창상 치유에 미치는 영향에 관한 실험적 연구

김성수

서울대학교 대학원 치의학과 구강외과학

EXPERIMENTAL STUDY ON THE EFFECTS OF CYCLOPHOSPHAMIDE ON THE HEALING OF THE ORAL INCISED WOUND

Seoung-Soo Kim

Dept. of Oral Surgery, Graduate School, Seoul National University

Abstract

To assure that cyclophosphamide has been considered something that must be effective to retard wound healing, the Author has studied clinically and histopathologically. All rabbits were incised on the mucogingival junction of anterior teeth in mandible about 1 Cm. in length with mucosa and periosteum layer. The 21 rabbits within 6 months old, weighing about 1.5-1.8 kg were divided into a experimental group and a control group. 1) Group 1 (Experimental group)-After 14 rabbits dieted as the control group were injected with Endoxan (=Cyclophosphamide) in dosage of 30mg per 1kg-body weight intramuscularly, the surgery was performed. 2) Group 2 (Control group)-the surgery in this group was performed without Endoxan. The rabbits were sacrificed on the 1st, 3rd, 5th, 7th, 10the, 14th day after surgery and microscopic slides were made with H-E stain. The results might be summarized as follows; 1) Cyclophosphamide effected to retard healing process on the incised wound of oral mucosa and connective tissue. 2) Control wounds were healed by the 7th day after surgery. 3) Comparison between control and experimental wound did not show significant differences 14th day after surgery.