| 타이타늄 임플란트 골유착시 성장인자들의 발현 ; TGF-beta, IGF-I, BMP2, BMP4 |
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지유진1, 김수현2 |
1경의대학교 동서신의학병원 치대병원 구강악안면외과
2가톨릭대학교 임상치과학대학원 |
| Expression of Growth factors during Osseointegration of Titanium Implant ; TGF-beta, IGF-I, BMP2, BMP4 |
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Yu-Jin Jee1, Soo-Hyun Kim2 |
1Department of Oral and Maxillofacical Surgery, Dental Hospital, East-West Neo Medical Center, Kyunghee Univeristy
2Graduate Shool of Clinical Dental Science, The Catholic University of Korea |
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| Abstract |
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Osseointegration is a result of bone formation and bone regeneration process, which take place at the interface between bone and implant and biologic determinants such as cytokine, growth factors, bone matrix proteins play an important role in osseointegration. The purpose of this study is to compare the expressoin of TGF-beta, IGF-I, BMP2, BMP4 during osseointegration. We designed an experimental group which was inserted with a RBM surface titanium implants and machined surface, and compared with a control group which had a simple bone cavity and normal bone. Titanium implants were placed into tibia of 8 rabbits. We compared the expression of TGF-beta, IGF-I, BMP2, BMP4 using RT_PCR (reverse transcriptase chain reaction)analysis in day 3,7,14 and 28 of implant insertion. According to the results, growth factors of experimental groups were more expressed than control groups. Among experimental groups, expression of TGF-beta, IGF-I, BMP4 of BMP group had tedency to increase more at 14th, 28th days than Machined surface group. Therefore, our results suggest that TGF-beta, IGF-I, BMP4 are expressed within the bone around the implant and more increased around rough surface implants while osseointegration occurs after dental implant insertion. |
| Key Words:
dental implant, growth factors, osseointegration. RT-PCR; |
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