Minocycline-induced discoloration of the alveolar bone: A case report

Park, Jung-Won

doi:2025.63.11.346

J Korean Dent Assoc > Volume 63(11); 2025 > Article

Case Report

Journal of Korean Dental Association 2025;63(11):346-352.
DOI: https://doi.org/10.22974/jkda.2025.63.11.002 Published online November 30, 2025.

Minocycline-induced discoloration of the alveolar bone: A case report

Jung-Won Park

Department of Oral and Maxillofacial Surgery, Inje University Busan Paik Hospital, Busan, Korea

Correspondence: Jung-Won Park, Tel: +82-51-890-6360,
Email: hanjw@gwnu.ac.kr

Received: 22 July 2025 • Revised: 23 October 2025 • Accepted: 24 October 2025

Abstract

Minocycline, a broad-spectrum tetracycline antibiotic, is known to cause tissue pigmentation, although involvement of alveolar bone is rare and often underrecognized. This report describes a case of blue-gray alveolar bone pigmentation discovered incidentally during extraction of bilaterally impacted mandibular third molars in a 17-year-old male. The patient had a history of prolonged minocycline use following orthopedic surgery. Despite the pigmentation, the affected bone demonstrated normal density and structure, and postoperative healing was uneventful. Although histopathologic confirmation was not pursued, the patient’s medical history and clinical presentation were consistent with minocycline-induced pigmentation. Awareness of this uncommon condition is essential to prevent misdiagnosis, avoid unnecessary intervention, and reassure patients. Current evidence suggests that such pigmentation does not adversely affect bone quality or healing capacity. This case highlights the importance of recognizing minocycline-induced bone pigmentation to prevent misdiagnosis and unnecessary intervention.

Key Words: Minocycline; Pigmentation; Drug-Related Side Effects and Adverse Reactions; Mandible