Angioleiomyoma of the hard palate: Report of a case and clinical, imaging, immunohistochemical analysis

Chang, Euijune; Ahn, Donggi; Kim, Jun-Young

doi:2025.63.7.223

J Korean Dent Assoc > Volume 63(7); 2025 > Article

Case Report

Journal of Korean Dental Association 2025;63(7):223-227.
DOI: https://doi.org/10.22974/jkda.2025.63.7.002 Published online July 31, 2025.

Angioleiomyoma of the hard palate: Report of a case and clinical, imaging, immunohistochemical analysis

Euijune Chang¹

, Donggi Ahn²

, Jun-Young Kim¹

¹Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Seoul, Korea
²Department of Oral Pathology, Yonsei University Dental Hospital, Yonsei University Health System, Seoul, Korea

Correspondence: Jun-Young Kim, Tel: +82-2-2228-3141,
Email: jyomfs@yuhs.ac

Received: 12 May 2025 • Revised: 27 May 2025 • Accepted: 4 June 2025

Abstract

Angioleiomyoma, also known as vascular myoma or vascular leiomyoma, is a rare benign tumor originating from smooth muscle cells of the tunica media of blood vessels, characterized by numerous blood vessels and spindle-shaped smooth muscle cells. A 40-year-old Korean female was referred with a 14 × 8 × 6 mm pedunculated, elastic mass on the right hard palate. She reported the lesion had been present for one year without pain or noticeable growth. MRI showed a uniform signal pattern with heterogeneous hypo-intensity on T1-weighted and hyper-intensity on T2-weighted images. The tumor was excised under local anesthesia. Histopathology showed cytoplasmic positivity for SMA, Desmin, and Caldesmon, and negativity for pan-cytokeratin, S-100, CD31, CD34, and HMB45. Based on these findings, the lesion was diagnosed as angioleiomyoma. This represents the first reported case of angioleiomyoma occurring in the hard palate in Korea.

Key Words: Leiomyoma; Hard palate tumor; Oral neoplasm; Magnetic Resonance Imaging(MRI); Immunohistochemistry