Effect of Collagen Plug and Bone Graft on Bone Formation in Rabbit Extraction Model

Park, Jisu; Song, Gun; Kim, Hye Jin; Ryu, Jaeyoung; Jung, Seunggon; Kook, Min-Suk; Oh, Hee-Kyun; Park, Hong-Ju

doi:2024.62.10.606

J Korean Dent Assoc > Volume 62(10); 2024 > Article

Original Article

The Journal of The Korean Dental Association 2024;62(10):606-618.
DOI: https://doi.org/10.22974/jkda.2024.62.10.002 Published online October 31, 2024.

Effect of Collagen Plug and Bone Graft on Bone Formation in Rabbit Extraction Model

Jisu Park

Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental science Research Institute, Chonnam National University

Correspondence: Hong-Ju Park, Tel: +82-62-220-5436, Fax: +82-62-220-5437,
Email: omspark@jnu.ac.kr

Received: 14 July 2024 • Revised: 18 July 2024 • Accepted: 13 August 2024

Abstract

1. Purpose
This study aimed to investigate the differences in bone regeneration capacity following extraction between a control group without biomaterial placement and experimental groups where biomaterials were inserted (including xenograft, synthetic bone-containing collagen plugs, and collagen plugs).
2. Materials and Methods
Bilateral extraction of maxillary first premolars or second premolars was performed, dividing the rabbits into four groups [① Group 1 :no bone graft or collagen plug inserted, ② Group 2: collagen plug inserted after extraction, ③ Group 3: collagen plug containing synthetic bone inserted after extraction, ④ Group 4: xenograft material inserted after extraction]. After euthanized the rabbit, Four and eight weeks postoperatively, the extent of bone formation were evaluated histologically and radiographically.
3 Results
The degree of new bone formation using histological analysis showed higher results in both the control groups at weeks 4 and 8, although not statistically significant. Across all groups, higher bone formation was observed at 8 weeks compared to 4 weeks. In radiological analysis using micro CT, Bone Mineral Density (BMD) and Bone Volume/Tissue Volume(BV/TV) were highest in Group 4. Trabecular bone thickness(Tb.Th) was highest in the control group, but not statistically significant.
4. Conclusion
In all groups, the degree of new bone formation at 4 and 8 weeks did not show statistically significant differences histologically and radiologically.

Key Words: Bone graft, collagen plug, Xenograft