Reviews of the Therapeutic Effect of Resveratrol Application for Arthritis : Focused on Animal Experiments

Hyun, Seung-Chul; Kwon, Jung-Wook; Kim, Dong-Hyuck; Lee, Eui-Seok; Lim, Ho-Kyung

doi:2023.61.13.852

J Korean Dent Assoc > Volume 61(13); 2023 > Article

REVIEW ARTICLE

The Journal of The Korean Dental Association 2023;61(13):852-861.
DOI: https://doi.org/10.22974/jkda.2023.61.13.003 Published online December 31, 2023.

관절염에 대한 Resveratrol 적용의 치료 효과 리뷰 : 연구논문을 통한 동물 실험 고찰

현승철

고려대학교 구로병원 구강악안면외과

Reviews of the Therapeutic Effect of Resveratrol Application for Arthritis : Focused on Animal Experiments

Seung-Chul Hyun

Department of Oral and Maxillofacial Surgery, Korea University Guro Hospital, Seoul, South Korea

Correspondence: Ho-Kyung Lim, Tel: 82-2-2626-1523, Fax: 82-2-2626-2024,
Email: ungassi@naver.com

Received: 8 September 2023 • Revised: 18 September 2023 • Accepted: 24 November 2023

Abstract

Temporomandibular disorders (TMD) are challenging to treat despite various existing methods. Stress on the temporomandibular joint (TMJ) leads to an accumulation of reactive oxygen species, promoting inflammation and cartilage degra-dation. Resveratrol, a natural polyphenol, inhibits inflammatory pathways and suppresses chondrocyte apoptosis, making it a promising candidate for TMD treatment. This review analyzes six studies with 3 kinds of animals on the intra-articular application of resveratrol for treating arthritis. This paper aims to elucidate the potential of resveratrol administrations into the articular cartilage to improve severity of arthritis, providing a foundation for future research and clinical investigations.

Key Words: Temporomandibular disorders; Arthritis; Resveratrol; Anti-inflammatory agents