Effect of pentoxifylline and tocopherol for MRONJ patients: A systematic review

Kim, Moo-Kyeong; Kim, Hyun-Je; Kim, Dong-Hyuck; Lee, Eui-Seok; Lim, Ho-Kyung

doi:2022.60.11.694

J Korean Dent Assoc > Volume 60(11); 2022 > Article

ORIGINAL ARTICLE

The Journal of The Korean Dental Association 2022;60(11):694-703.
DOI: https://doi.org/10.22974/jkda.2022.60.11.002 Published online October 31, 2022.

약물 관련 악골 괴사증 (MRONJ) 환자에서 Pentoxifylline and Tocopherol의 효과: 문헌고찰

김무경

고려대학교 구로병원 구강악안면외과

Effect of pentoxifylline and tocopherol for MRONJ patients: A systematic review

Moo-Kyeong Kim

Department of Oral and Maxillofacial Surgery, Korea University Guro Hospital

Correspondence: Ho-Kyung Lim, Tel: 82-2-2626-1523, Fax: 82-2-2626-2024,
Email: ungassi@naver.com

Received: 26 July 2022 • Revised: 28 July 2022 • Accepted: 21 September 2022

Abstract

MRONJ (medication related osteonecrosis of the jaw) is a disease characterized by necrosis of the jaw that occurs after administration of anti-resorptive or anti-angiogenic drugs. However, etiology and effective treatment methods of MRONJ are not yet clearly identified. In this study, a systematic review was conducted to investigate the effects of pentoxifylline and tocopherol on MRONJ. A total of 5 clinical studies using pentoxifyllie and tocopherol in MRONJ patients among the papers registered in Pubmed/medline were reviewed. Pentoxifyllie and tocopherol were used for therapeutic purposes in 32 patients, and the mean age was 68 years for men and 74.21 years for women. Of the 32 patients, 20 patients were stage 2, 11 patients were stage 3, and one patient was stage 0. In the most cases, the triggering factor was extraction. All patients com-plained of pain in the lesion area before drugs administration. The average follow-up period was 10.6 months. After drugs administration, 29 patients (90.6%) showed improvement in symptoms in terms of bone exposure and pain. Administration of pentoxifylline and tocopherol in MRONJ may improve symptoms of pain and bone exposure. However, it seems that additional studies on the appropriate use and dose, timing and duration of administration are needed.

Key Words: Medication-related osteonecrosis; Pentoxifylline; Tocopherol; Jaw