A scoping review on the effectiveness of mouth rinse against SARS-CoV-2

Lee, Joo-Young; Kim, Hyo-Jung; Jung, Hoi-In; Kim, Baek-Il

doi:2022.60.7.422

J Korean Dent Assoc > Volume 60(7); 2022 > Article

ORIGINAL ARTICLE

The Journal of The Korean Dental Association 2022;60(7):422-435.
DOI: https://doi.org/10.22974/jkda.2022.60.7.002 Published online June 30, 2022.

코로나바이러스(SARS-CoV-2)에 대한 구강 양치액의 효과: 주제 범위 문헌고찰

이주영¹

, 김효정¹

, 정회인^1,2

, 김백일^1,2

^¹연세대학교 치과대학 예방치과학교실, BK²¹ 창의치의학융합 교육연구단
^²연세대학교 치과대학병원 의료기기사용적합성센터

A scoping review on the effectiveness of mouth rinse against SARS-CoV-2

Joo-Young Lee¹

, Hyo-Jung Kim¹

, Hoi-In Jung^1,2

, Baek-Il Kim^1,2

¹Department of Preventive Dentistry & Public Oral Health, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Republic of Korea
²Innovation Research and Support Center for Dental Science, Yonsei University Dental Hospital, Seoul, Republic of Korea

Correspondence: Baek-Il Kim
Email: drkbi@yuhs.ac

Received: 8 April 2022 • Revised: 13 April 2022 • Accepted: 19 May 2022

Abstract

Although studies reporting the efficacy of mouth rinse against SARS-CoV-2 have been continuously published, it is chal-lenging to select literature through qualitative meta-synthesis or quality assessment of the study. Therefore, this study aims to systematically review the efficacy of mouth rinse against SARS-CoV-2 using the scoping review method and to provide the latest information. Literature search on electronic databases (PubMed, Scopus, and Cochrane Trials) was conducted. After establishing liter-ature inclusion and exclusion criteria, two independent researchers were selected literatures. Of the 15 articles were included in this scoping review, 11 were in vitro studies, and four were in vivo studies. The ingredients tested in these studies were povidone-iodine, chlorhexidine, hydrogen peroxide, essential oils, and qua-ternary ammonium compounds, and they showed various efficacy against SARS-CoV-2. Despite the relatively limited evidence from the included studies, the use of mouth rinse has the potential to reduce the viral load of SARS-CoV-2. In particular, povidone-iodine is expected to be the most effective against SARS-CoV-2, given the evidence so far.

Key Words: COVID-19; mouth rinse; povidone-iodine; SARS-CoV-2; virus