Root coverage achieved with a connective tissue graft overlaid onto allogeneic demineralized dentin matrix incorporated with rhBMP-2

Kwak, Han-wool; Um, In-Woong; Ku, Jeong-Kui

doi:2023.61.11.706

J Korean Dent Assoc > Volume 61(11); 2023 > Article

ORIGINAL ARTICLE

Journal of Korean Dental Association 2023;61(11):706-712.
DOI: https://doi.org/10.22974/jkda.2023.61.11.002 Published online October 31, 2023.

Root coverage achieved with a connective tissue graft overlaid onto allogeneic demineralized dentin matrix incorporated with rhBMP-2

Han-wool Kwak¹

, In-Woong Um²

, Jeong-Kui Ku¹

¹Department of Oral and Maxillofacial Surgery, School of Dentistry and Institute of Oral Bioscience, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University
²R&D Institute, Korea Tooth Bank

Correspondence: Jeong-Kui Ku
Email: kujk@jbnu.ac.kr

Received: 14 June 2023 • Revised: 4 July 2023 • Accepted: 7 September 2023

Abstract

Autogenous demineralized dentin matrix (DDM) has been widely used in implant dentistry and highlighted as a potential carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2). Allogeneic DDM (Allo-DDM) is comparable to autogenous DDM in safety and effectiveness. The various endogenous growth factors in dentin, including BMP, transform-ing growth factor, fibroblast growth factor, and insulin growth factor suggest that DDM incorporated with rhBMP-2 (DDM/ rhBMP-2) may exert a synergistic effect that promotes soft tissue healing through angiogenic activity, in addition to its osteoinductivity. This case report describes a successful outcome of root coverage where connective tissue graft (CTG) was overlaid onto Allo-DDM incorporated with rhBMP-2 (Allo-DDM/rhBMP-2).

Key Words: demineralized dentin matrix; connective tissue graft; fistula closure; dentistry; root coverage