| 유치치수유래 줄기세포치료제의 조직재생 임상적용 위한 가능성 고찰 |
김병규1 
, 윤지영2,3
, 신성진3,5
, 김형은2
, 이승민2
, 김해원1,3,4,5
, 이해형1,3,4
, 이정환1,2,3,4,5
|
1단국대학교 생체재료학교실
2(주)셀앤매터 줄기세포물질 연구소
3단국대학교 조직재생공학연구원
4단국대학교 나노바이오의학과 BK21 plus 재생의학 글로벌리서치센터
5MRC 메카노바이올로지 치의학연구 센터 |
| Clinical potential of deciduous teeth-derived dental pulp-derived stem cell therapy for tissue regeneration |
|
Byunggyu Kim1
, Ji-Young Yoon2,3
, Seong-Jin Shin3,5
, Hyung-Eun Kim2
, Seung Min Lee2
, Hae-Won Kim1,3,4,5
, Hae-Hyoung Lee1,3,4
, Jung-Hwan Lee1,2,3,4,5
|
1Department of Biomaterials Science, College of Dentistry, Dankook University
2Institute for Stem Cell & Matters, Cell & Matter Corporation
3Institute of Tissue Regeneration Engineering (ITREN), Dankook University
4Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University
5Mechanobiology Dental Medicine Research Center, Dankook University |
Correspondence:
Jung-Hwan Lee, Tel: +82 41 550 3081, Fax: +82 41 559 7839,
Email: ducious@gmail.com
|
|
Received: 9 January 2024 • Revised: 19 January 2024 • Accepted: 31 January 2024 |
| Abstract |
|
Dental pulp stem cells are mesenchymal stem cells derived from the dental pulp tissue of permanent or deciduous teeth. Especially, stem cells from human exfoliated deciduous teeth (SHED) have an enhanced capacity than adult pulp stem cells counterpart
for self-renewal (proliferation) and multilineage differentiation, being able to generate dentin/pulp-like complexes, neural cells, skin cells, chondrocytes, and osteogenic cells, among others. Their accessibility from routine dental procedures and lack of ethical concerns make SHED an attractive stem cell source for regenerative therapy. This paper reviews current preclinical and clinical research on the tissue regenerative potential of SHED-based therapies. In preclinical animal models and clinical trials, SHED transplantation have shown promise for bone regeneration and repair, neural regeneration, myocardial infarction treatment, inflam-matory bowel disease, renal injury, liver fibrosis, diabetes mellitus, erectile dysfunction, skin wounds, muscle injury, and other con-ditions. Early-phase human trials further indicate the feasibility, safety, and efficacy of SHED based cell therapy for various disease introduced before. However, therapeutic effects from SHED injections vary greatly depending on cell source, delivery method, dose, and disease model or condition. Additional translational medicine studies for elucidating key therapeutic mechanisms of SHED and methodological advances in cell processing and delivery are needed to improve consistency. If the remaining challenges are addressed through rigorous research, SHED cell therapy may become versatile clinical (dental) materials for tissue repair and
regeneration across a wide range of organs and disease states. |
| Key Words:
Dental pulp stem cells; SHED; Tissue regeneration; Cell therapy; Translational medicine; Dental materials |
|
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