| 구강조직유래 유도만능줄기세포-생체재료 복합체의 재생의료 동향 |
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전수경1, 이해형2, 김해원3, 이정환4 |
1단국대학교 생체재료학교실
2단국대학교 생체재료학교실
3단국대학교 생체재료학교실
4단국대학교 생체재료학교실 |
| Regenerative medicine using dental tissue derived induced pluripotent stem cell-biomaterials complex |
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Soo-Kyung Jun1, Hae-Hyoung Lee2, Hae-Won Kim3, Jung-Hwan Lee4 |
1Department of Biomaterials Science, College of Dentistry, Dankook University
2Department of Biomaterials Science, College of Dentistry, Dankook University
3Department of Biomaterials Science, College of Dentistry, Dankook University
4Department of Biomaterials Science, College of Dentistry, Dankook University |
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| Abstract |
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In recent years, many researchers and clinicians found interest in regenerative medicine using induced pluripotent stem cells (iPSCs) with biomaterials due to their pluripotency, which is able to differentiate into any type of cells without human embryo, which of use is ethically controversial. However, there are limitations to make iPSCs from adult somatic cells due to their low stemness and donor site morbidity. Recently, to overcome above drawbacks, dental tissue-derived iPSCs have been highlighted as a type of alternative sources for their high stemness, easy gathering, and their complex (ectomesenchymal) origin, which easily differentiate them to various cell types for nerve, vessel, and other dental tissue regeneration. In other part, utilizing biomaterials for regenerative medicine using cell is recently highlighted because they can modulate cell adhesion, proliferation and (de)differentiation. Therefore, this paper will convey the overview of advantages and drawbacks of dental tissue-derived iPSCs and their future application with biomaterials. |
| Key Words:
Regenerative medicine;dental tissue derived;induced pluripotent stem cell;biomaterials; |
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