| MRONJ 예방과 치료를 위한 최신지견 |
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박정현1, 김선종2 |
1이화여대목동병원 구강악안면외과
2이화여대 의학전문대학원 치과학교실 구강악안면외과, 난치성 악골괴사질환연구센터 |
| Contemporary Concept for Prevention and treatment of MRONJ (Medication Related Osteonecrosis of Jaw) |
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Jung-Hyun Park1, Sun-Jong Kim2 |
1Division of Oral and Maxillofacial Surgery, Ewha Medical Center
2Division of Oral and Maxillofacial Surgery/Research Center for ONJ, School of Medicine, Ewha Womans University |
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| Abstract |
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Bisphosphonates are widely used mainly for the treatment of osteoporosis and bone metastasis of malignancy. Since the first report of MRONJ, there have been many studies associated, however the pathogenesis of MRONJ is not yet clear. Medication-related osteonecrosis of the jaws (MRONJ) is a serious complication associated with long-term medication therapy. It is characterized by exposed necrotic bonein the jaw, which has persisted for more than 8weeks despite continuous treatment by dentist. The mechanism of development of MRONJ is still unclear and there is no definitive standard treatment for MRONJ. The purpose of this study is to investigate the jaw bone destruction mechanism of accumulated bisphosphonates, so that we can develop therapeutic method to repair the defect and stop the destruction process. The authors performed simultaneous application of PRF(Platelet rich fibrin) and BMP-2(Bone morphogenetic protein-2) to stimulate not only soft tissue healing but also osseous regeneration. Our case series demonstrate that simultaneous application of platelet rich fibrin and bone morphogenetic protein-2 can be a treatment of choice for MRONJ. |
| Key Words:
Bisphosphonate;Osteonecrosis of the jaw;Bone morphogenetic proteins;Platelet rich fibrin;Regeneration; |
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