| 지연된 의도적 재식술을 통한 치주 조직 재생 방법의 고찰 |
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김유경1, 김동주2, 이은웅3, 임현창4, 이중석5, 정의원6, 윤정호7, 김의성8, 이승종9, 최성호10 |
1연세대학교 치과대학 치주과학교실, 치주조직재생연구소
2연세대학교 치과대학 치주과학교실, 치주조직재생연구소
3연세대학교 치과대학 치주과학교실, 치주조직재생연구소
4연세대학교 치과대학 치주과학교실, 치주조직재생연구소
5연세대학교 치과대학 치주과학교실, 치주조직재생연구소
6연세대학교 치과대학 치주과학교실, 치주조직재생연구소
7인하대학교 의과대학 치과학교실
8연세대학교 치과대학 보존과학교실
9연세대학교 치과대학 치주과학교실, 치주조직재생연구소
10연세대학교 치과대학 치주과학교실, 치주조직재생연구소 |
| Delayed intentional replantation: new approach for periodontal regeneration and establishment of theoretical background |
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You-Kyoung Kim1, Dong-Ju Kim2, Eun-Ung Lee3, Hyun-Chang Lim4, Jung-Seok Lee5, Ui-Won Jung6, Jeong-Ho Yun7, Eui-Seong Kim8, Seong-Jong Lee9, Seong-Ho Choi10 |
1Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
2Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
3Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
4Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
5Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
6Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
7Department of Dentistry, School of Medicine, Inha University
8Department of Conservative Dentistry, College of Dentistry, Yonsei University
9Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
10Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University |
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| Abstract |
Purpose
Delayed intentional replantation was introduced as a new alternative to treat the teeth with severe periodontal involvement. The purpose of this study was to elucidate the possibility of delayed intentional replantation and establish theoretical backgrounds. Materials and Methods: Studies were performed into the following two subjects; (1)Clinical evaluation of patients who underwent delayed intentional replantation using clinical and radiographic data. Severe periodontitis involved teeth were carefully extracted and proper time for delayed replantation was evaluated by analyzing inflammation markers (IL-6, TNF-alpha). (2) Theoretical studies for efficacy of delayed intentional replantation using (-)-Epigallocatechin-3-gallate (EGCG) for preservation of periodontal ligament cells on root surface by minimizing inflammation and treatment of inflammatory extraction sockets. Results: Meaningful success ratio and survival rate were found in delayed intentional replantation showing reduced bone loss and maintained bone level. Additionally, viability of EGCG applied periodontal ligament cells was much higher than control group. Also, EGCG promoted healing of inflammatory extraction sockets by inhibiting inflammatory cell proliferation. Conclusion: Within the limitations of this study, 1-2 weeks after extraction is an appropriate time to do delayed intentional replantation. Also, EGCG provides helpful effects on viability of periodontal ligament cells and periodontium. |
| Key Words:
Delayed intentional replantation;Tooth extraction;Periodontitis;(-)-Epigallocatechin-3-gallate (EGCG);Anti-inflammatory effect; |
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