| 성견의 발치와 협측골 외측에 적용한 교원질 차단막과 재조합 골형성단백질의 치조제 보존 효과 |
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임현창1, 김민수2, 양혜주3, 이중석4, 최성호5, 정의원6 |
1경희대학교 치과대학 치주과학교실
2연세대학교 치과대학 치주과학교실, 치주조직재생연구소
3연세대학교 치과대학 치주과학교실, 치주조직재생연구소
4연세대학교 치과대학 치주과학교실, 치주조직재생연구소
5연세대학교 치과대학 치주과학교실, 치주조직재생연구소
6연세대학교 치과대학 치주과학교실, 치주조직재생연구소 |
| Application of rhBMP-2 loaded collagen membrane on the buccal plate for ridge preservation: a pilot study in dogs |
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Hyun-Chang Lim1, Min-Soo Kim2, Cheryl Yang3, Jung-Seok Lee4, Seong-Ho Choi5, Ui-Won Jung6 |
1Department of Periodontology, School of Dentistry, Kyung Hee University
2Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
3Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
4Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
5Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University
6Research Institute for Periodontal Regeneration, Department of Periodontology, College of Dentistry, Yonsei University |
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| Abstract |
Objective
The aim of this study was to determine the effect of multi-layer of a collagen membrane alone or loaded rhBMP-2 on the buccal plate for ridge preservation after tooth extraction. Material and methods: Following bilateral extraction of the maxillary 1st and 3rd premolars in five dogs, rhBMP-2 loaded collagen membrane was applied to the buccal plates at the 1st premolar and collagen membrane only was applied to the buccal plates at the 3rd premolar unilaterally. The collagen membranes applied in the experimental groups were piled into four layers. The corresponding sites of the contralateral side healed naturally. After 3months of healing, the animals were sacrificed. Radiographic and histologic analyses were performed. Results: There was no significant difference in the healing of extraction socket at both 1st and 3rd premolars. In microcomputed tomography, the widths of the residual ridge of the experimental groups were similar with the controls. Histologically, the experimental groups did not exhibit different pattern compared to the controls regardless of the addition of rhBMP-2. Conclusion: Layering of the collagen membrane with or without rhBMP-2 on the buccal plate failed to show the effectiveness in dimensional preservation of the extraction socket. |
| Key Words:
collagen membrane;rhBMP-2;ridge preservation;ridge resorption; |
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