Bone regeneration in oral and maxillofacial field using rhBMP-2

Hwang,  Soon Jung; Park,  Min-Woo; Park,  Jae bong; Park,  Hyun Soo; Paek,  Seung-Jun; Sul,  Hee-Kyung; Lee,  Kyung jin; Hong,  Dong-Hwan

J Korean Dent Assoc > Volume 53(1); 2015 > Article

The Journal of The Korean Dental Association 2015;53(1):28-35.
Published online January 31, 2015.

rhBMP-2의 작용기전과 구강악안면 영역의 골재생을 위한 rhBMP-2의 활용

황순정¹, 박민우², 박재봉³, 박현수⁴, 백승준⁵, 설희경⁶, 이경진⁷, 홍동환⁸

^¹서울대학교 치의학대학원/치과병원 구강악안면외과
^²서울대학교 치의학대학원/치과병원 구강악안면외과
^³서울대학교 치의학대학원/치과병원 구강악안면외과
^⁴서울대학교 치의학대학원/치과병원 구강악안면외과
^⁵서울대학교 치의학대학원/치과병원 구강악안면외과
^⁶서울대학교 치의학대학원/치과병원 구강악안면외과
^⁷서울대학교 치의학대학원/치과병원 구강악안면외과
^⁸서울대학교 치의학대학원/치과병원 구강악안면외과

Bone regeneration in oral and maxillofacial field using rhBMP-2

Soon Jung Hwang¹, Min-Woo Park², Jae bong Park³, Hyun Soo Park⁴, Seung-Jun Paek⁵, Hee-Kyung Sul⁶, Kyung jin Lee⁷, Dong-Hwan Hong⁸

¹Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University
²Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University
³Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University
⁴Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University
⁵Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University
⁶Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University
⁷Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University
⁸Dept. of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, School of Dentistry, Seoul National University

Abstract

To overcome shortcoming of autogeneous, allogenic, xenogenic and alloplastic bone grafts, various growth factors related to bone regeneration have been identified and developed. Among them, rhBMP-2 is regarded as the most potent osteoinductive growth factor and it can trigger the differentiation of mesenchymal stem cells to osteogenic cells for accelerated new bone formation And several commercial products of rhBMP-2 are available in Korea. It is applied to maxillary sinus augmentation, guided bone regeneration and preservation of extraction socket. In this review, the development, action mechanism and clinical applications of rhBMP-2 will be described.

Key Words: rhBMP-2;carrier;alveolar bone;oral and maxillofacial bone regeneration;