Successful strategy of treatment used to rhBMP-2 and LFA-collagen scaffold for BRONJ

Kwon,  Kyung-Hwan

J Korean Dent Assoc > Volume 52(4); 2014 > Article

The Journal of The Korean Dental Association 2014;52(4):218-233.
Published online April 30, 2014.

임상가를 위한 특집 3 - rhBMP-2와 LFA-collagen scaffold를 이용한 BRONJ의 성공적인 치료 전략

권경환

원광대학교 치과대학병원 구강악안면외과, 원광치의학연구소

Successful strategy of treatment used to rhBMP-2 and LFA-collagen scaffold for BRONJ

Kyung-Hwan Kwon

Department of oral and maxillofacial surgery, college of dentistry, Wonkwang university Wonkwang dental research institute

Abstract

Bispbosphonates are a class of pharmaceutic agents, which induce apoptosis of osteoclast as well as impair osteoclastic activity to suppress bone resorption. Thus, bisphophonates are effectively used to treat osteoporosis, multiple myeloma and to prevent bone metastases of malignant cancer. However, recently dental disease have been reported associated with Bisphosphonates. Thus, there are a number of discussions about proper prevention and treatment of bisphosphonate-related osteonecrosis of jaw(BRONJ). Marshall R. Urist in 1965 made the seminal discovery that a specific protein, BMP(bone morphogenetic protein), found in the extracellular matrix of demineralized bone could induce bone formation newly when implanted in extraosseous tissues in a host. BMPs are multi-functional growth factors which are members of the transforming growth factor-beta super family and their ability is that plays a pivotal roll in inducing bone. About 18 BMP family members have been identified and characterized. Among of them, BMP-2 and BMP-7 have significant importance in bone development. In this study, patients of BRONJ were recieved who visited Department of oral and maxillofacial surgery, school of dentistry, Wonkwang university for past 3 years from 2011 to 2013. We focused on the results of the surgical intervention. We suggest that new strategy of treatment used to rhBMP-2 and LFA(Lidocaine-Fibrinogen-Aprotinin)-collagen scaffold for patients of BRONJ. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on rhBMP-2 and LFA collage scaffold.

Key Words: rhBMP-2;BRONJ;scaffold;collagen;