New biomarkers of dental caries: nitric oxide and glutathione

Han,  Dong-Hun; Kim,  Min-Ji; Jun,  Eun-Joo; Kim,  Jin-Bom

J Korean Dent Assoc > Volume 50(9); 2012 > Article

The Journal of The Korean Dental Association 2012;50(9):558-565.
Published online September 30, 2012.

임상가를 위한 특집 3 - 치아우식증의 새로운 생체지표: nitric oxide와 glutathione

한동헌¹, 김민지², 전은주³, 김진범⁴

^¹서울대학교 치의학대학원 예방치학교실
^²부산대학교 치의학전문대학원 예방치과학교실
^³부산대학교 치의학전문대학원 예방치과학교실
^⁴부산대학교 치의학전문대학원 예방치과학교실

New biomarkers of dental caries: nitric oxide and glutathione

Dong-Hun Han¹, Min-Ji Kim², Eun-Joo Jun³, Jin-Bom Kim⁴

¹Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University
²Department of Preventive and Community Dentistry, School of Dentistry, Pusan National University
³Department of Preventive and Community Dentistry, School of Dentistry, Pusan National University
⁴Department of Preventive and Community Dentistry, School of Dentistry, Pusan National University

Abstract

Dental caries is multifactorial local disease which involves destruction of the hard tissues of the teeth by metabolities produces by microorganisms. Recently, there has been growing interest in the role of nitric oxide (NO) and glutathione (GSH) in caries incidence. The aim of the study was to survey the studies reported the association among salivary NO, GSH and dental careis. Three studies reported the association between NO and dental caries. However, the results were contradictory. Only one study showed negative association between GSH and dental caries. In Korea, NO showed negative association with Lactobacilli and GSH showed positive association with dental caries. These observations suggest the possibility that NO and GSH could be new biomarkers for dental caries. However, further study should be needed.

Key Words: nitric oxide;glutathione;dental caries;