Clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN(R)) in periodontal disease : Double blind, randomized control study

Chang,  Yun-Young; Jang,  Yong-Ju; Jung,  Im-Hee; Um,  Yoo-Jung; Jung,  Ui-Won; Kim,  Chang-Sung; Kim,  Baek-Il; Choi,  Seong-Ho

doi:2009.47.12.830

J Korean Dent Assoc > Volume 47(12); 2009 > Article

Journal of Korean Dental Association 2009;47(12):830-837.
DOI: https://doi.org/10.22974/jkda.2009.47.12.007 Published online December 31, 2009.

중등도 치주질환에 대한 Vitamin C, Vitamin E, lysozyme, carbazochrome (이가탄(R)) 복합제제의 임상 효과

장윤영¹, 장용주², 정임희³, 엄유정⁴, 정의원⁵, 김창성⁶, 김백일⁷, 최성호⁸

^¹연세대학교 치과대학 치주과학교실, 치주조직재생연구소
^²연세대학교 치과대학 치주과학교실, 치주조직재생연구소
^³연세대학교 치과대학 치주과학교실, 치주조직재생연구소
^⁴연세대학교 치과대학 치주과학교실, 치주조직재생연구소
^⁵연세대학교 치과대학 치주과학교실, 치주조직재생연구소
^⁶연세대학교 치과대학 치주과학교실, 치주조직재생연구소
^⁷연세대학교 치과대학 예방치과학교실
^⁸연세대학교 치과대학 치주과학교실, 치주조직재생연구소

Clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN(R)) in periodontal disease : Double blind, randomized control study

Yun-Young Chang¹, Yong-Ju Jang², Im-Hee Jung³, Yoo-Jung Um⁴, Ui-Won Jung⁵, Chang-Sung Kim⁶, Baek-Il Kim⁷, Seong-Ho Choi⁸

¹Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University
²Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University
³Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University
⁴Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University
⁵Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University
⁶Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University
⁷Department of preventive dentistry and public oral health College of dentistry, Yonsei university
⁸Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University

Abstract

Purpose
The purpose of this study was to evaluate the clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN(R)) for periodontal disease. Material and Methods : The study was performed by double blinded, ramdomized method. Forty two subjects diagnosed as chronic incipient or moderate periodontitis at department of periodontology, Yonsei Dental Hospital were included in the study. This study was approved by Institutional Review Board, Yonsei University Hospital. All subjects received scaling at their first examination and second examination was scheduled after 2 weeks. At second examination, periodontal parameters such as plaque index(PI), gingival index(GI), probing depth(PD), bleeding on probing(BOP), gingival recession(GR) and clinical attachment level(CAL) were recorded(Baseline) with prescription of Vitamin C, Vitamin E, lysozyme, carbazochrome complex(IGATAN(R)) (Experimental group 23 subjects) or placebo medicine(Control group; 19 subjects). The subjects were recalled after 4 weeks for periodontal parameters measurement. Results : In the experimental groups, PI, GI, CAL and BOP scores were significantly reduced at 4 weeks compared to baseline. A statistically significant decrease in or and BOP scores were observed in the experimental group compared to the control group. Conclusion : It can be concluded that Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN(R)) have an effect in reducing gingival bleeding and improving periodontal inflammatory condition inchronic incipient- moderate periodontitis.

Key Words: Vitamin C;Vitamin E;lysozyme;carbazochrome;