THE EXPERIMENTAL STUDY ON THE INFLUENCE OF SUCROSE-OVERDOSAGE ON RAT ORAL MUCOSA

Rhee,  Choon-Geun

J Korean Dent Assoc > Volume 19(2); 1981 > Article

The Journal of The Korean Dental Association 1981;19(2):163-166.
Published online February 28, 1981.

과당투여가 가토 구강점막조직에 미치는 영향에 관한 연구

이춘근

서울대학교 치과대학

THE EXPERIMENTAL STUDY ON THE INFLUENCE OF SUCROSE-OVERDOSAGE ON RAT ORAL MUCOSA

Choon-Geun Rhee

Dept. of Oral Surgery, College of Dentistry, Seoul National University

Abstract

Sugar consumption has been increased in recent days according to an improvement in living conditions. It is generally accepted that sugar is one of the causes of caries and that diabetes mellitus is closely related to the periodontal diseases. This investigation was designed to gain informations on the influence of overdosage of sugar and/or high blood sugar level on the periodontal tissue. 12 rats weighing about 1.5Kg were divided into 4 groups, control one and 3-day, 7-day, 14-day ones after daily administration of 30-50 gm of sucrose. The results were as follows: 1. Daily adminisration of 30-50 gm of sucrose elevated blood glucose level as much as 10-20 mg% than before. 2. Epithelial keratinization was gradually conspicuous to the dosage of sucrose. 3. The severity of inflammatory infiltration was also increased to the dosage of sucrose. 4. Inflammatory infiltration was encountered in marginal gingiva more than other periodontal tissue.