EXPERIMENTAL STUDY ON THE EFFECTS OF THE ANTICANCER AGENT(ENDOXAN) TO THE RAT'S TEETH

Yang,  Dong-Kyu

J Korean Dent Assoc > Volume 15(9); 1977 > Article

The Journal of The Korean Dental Association 1977;15(9):749-753.
Published online September 30, 1977.

항암제가 치아조직에 미치는 영향에 관한 실험적 연구

양동규

서울대학교 치과대학

EXPERIMENTAL STUDY ON THE EFFECTS OF THE ANTICANCER AGENT(ENDOXAN) TO THE RAT'S TEETH

Dong-Kyu Yang

Dental School

Abstract

The author studied the effects of anticancer Endoxan to the rat's teeth. Two hundred pregnant rats were used. The experimental rats were given an intramuscular injection of Endoxan as nitrogen mustard derivatives 10mg. per 40gm of body weight. In order to investigate effects of Endoxan to the teeth of rats the control and experimental rats group wee sacrificed on 1,3,5,7 and 14days, and made preparation for histopathologic findings. The rusults were as follows: 1. In several days (about 5days) after injection of Endoxan, tooth germs of cap stage, bell stage, and dental lamina were irregular arranged form as compared with in the control group teeth. 2. Irregular arranged cell were recovered from 14days after injection of Endoxan.